Current Openings

Research Associate II/III (Preclinical Neuroscience)

Neurona Therapeutics is an early stage biotechnology company based in South San Francisco created to develop stem cell-based therapies for neurological disease. Our ideal Research Associate candidate is a self-motivated individual who has clearly demonstrated a passion for scientific research. This is a fantastic opportunity to join a small team, work on transformative science, and take part in building an exciting, science-driven company.

Responsibilities include:
  • Working with rodents including handling, dosing, surgical procedures and tissue collection
  • Observation and scoring of behavioral assays
  • Processing tissue for histology: Microtome and cryostat sectioning, staining, immunohistochemistry, imaging and quantitative analysis
  • Following experimental protocols and maintaining detailed and accurate records
  • Analyzing data, interpreting and communicating results
  • Conducting independent experiments and contributing to collaborative activities
Required Qualifications:
  • Bachelor’s degree with a minimum of 2-3 years of relevant experience, or Master’s degree in biology, neuroscience, or a related field (or equivalent)
  • Previous relevant lab experience with animal handling and supporting references
  • Strong interpersonal skills with demonstrated ability to contribute to a team
  • Clear, effective written and verbal communication
  • Experience with stem cell research is preferred

 
 
 

Manufacturing Associate II

Neurona Therapeutics is an early stage biotechnology company based in South San Francisco focused on the development of neuronal cell-based therapies for neurological diseases. Our ideal candidate is a self-motivated individual who has a passion for scientific research. This is a fantastic opportunity to join a small team, work on transformative science, and take part in building an exciting, science-driven company.

Responsibilities include:
  • Participate and execute small-scale and at-scale process development experiments and develop viable cGMP manufacturing processes for cell culture and cryopreservation.
  • Participate in the design, development, and implementation of processes to manufacture human neural cell therapeutics from pluripotent stem cells towards execution of the process on the manufacturing floor.
  • Assist with maintaining laboratories (equipment maintenance, calibration, cleaning and related documentation).
  • Participate in and execute cGMP manufacturing operations on the production floor.
  • Ensure all safety and compliance procedures are always followed.
  • Participate in the development, execution, and issue resolution associated with process equipment Commissioning, Qualification and Validation.
  • Participate in and drive raw material and vendor qualifications
  • Provide troubleshooting, technical support, and resolution of equipment, raw materials, and process issues on the manufacturing floor.
  • Write and revise controlled documentation (SOPs, Manufacturing Procedures (MPs), Forms, Technical Reports, etc.)
  • Lead resolution of Non-Conformances/Process Deviations and execution of Corrective and Preventive Actions (CAPA).
  • Collaborate with Quality and other functional groups internally and at CMO to resolve manufacturing events in a timely manner.
  • Assure appropriate escalation to various levels of management when personnel and environmental safety, equipment functionality, product supply, or quality are at risk.
  • Collaborate with Quality, Manufacturing Managers, CMO staff and Regulatory Compliance staff in cross-functional teams.
  • Present data at departmental meetings.
  • Must possess the ability to work independently or as a team.
Required Qualifications:
  • Bachelor’s degree in science or engineering with 2-5 years of industrial experience or equivalent.
Preferred Qualifications:
  • 2-5 years of industrial experience in cGMP operations.
  • Knowledge of cell culture operations and bioreactors
  • Knowledge of analytical equipment and computers
  • Knowledge of CFRs and cGMP requirements and ability to interpret and apply the knowledge
  • Ability to independently collaborate with outside vendors
  • Understanding of analytical methods for in-process testing requirements in the manufacturing area
  • Possess excellent troubleshooting skills, technical writing capability, presentation and interpersonal skills
  • Able to take initiative to improve work processes, develop innovative scientific methodologies and approaches to enhance process productivity.

 
 
 

Process Development Scientist

Neurona Therapeutics is an early stage biotechnology company based in South San Francisco focused on the development of neuronal cell-based therapies for neurological diseases. Our ideal candidate is a self-motivated individual who has a passion for scientific research. This is a fantastic opportunity to join a small team, work on transformative science, and take part in building an exciting, science-driven company.

Responsibilities include:
  • Develop, optimize, characterize, and scale-up a variety of processes (cell culture, harvest, fill, cryopreservation and thaw) for the manufacturing of neural cell-based therapeutics from human pluripotent stem cells.
  • Help lead technology transfer, training, and process monitoring activities at clinical manufacturing sites.
  • Contribute to the development of analytical assays and release specifications.
  • Provide manufacturing support. Participate in troubleshooting exercises to diagnose and resolve production problems through data analysis and process/equipment characterizations.
  • Present data at project, team, and company-wide meetings. Generate scientific reports and contribute to CMC sections of regulatory submissions.
  • Some travel to CMO sites may be required.
  • Must possess the ability to work independently or as a team.
  • Must maintain notebooks and electronic files associated with each experiment and prepare final experimental reports.
  • Manage product and material inventories as needed throughout studies.
Required Qualifications:
  • Ph.D. in Biochemical Engineering, life sciences or related scientific field with 0-2 years of industrial experience.
  • In depth experience in mammalian cell culture and/or culture and expansion of stem cells is a requirement.
  • Experience in flow cytometry, and development of production processes using bioreactors is necessary.
  • Pluripotent stem cell and neuroscience training would be desirable.
  • Experience in cell cryopreservation is a plus.
  • Excellent computer, organizational, written and verbal communication skills.
  • Familiarity with cGMP requirements preferred.
  • Must be able to work independently and in multi-disciplinary teams.
  • Able to take initiative to improve work processes, develop innovative scientific methodologies and approaches to enhance process productivity.

 
 
 

Preclinical Neuroscientist (I/II)

Neurona Therapeutics is a preclinical stage biotechnology company based in South San Francisco created to develop stem cell-based therapies for neurological disease. We have an opening for a Preclinical Neuroscientist who will contribute to ongoing programs and build new animal models to study modulation of neural circuits and support translational development of cellular therapeutics.

Responsibilities include:
  • Planning, designing, executing and analyzing preclinical studies in neurological models that integrate anatomical, behavioral and physiological endpoints to understand the safety and efficacy of transplanted neural cells
  • Establishing new preclinical models and performing in vivo and histological activities required to support translational development
  • Close collaboration with a cross-disciplinary teams and external groups to coordinate and drive complex studies
  • Training and supervising research associates
  • Communicating results in written and oral formats for internal and external presentations
  • Preparing scientific presentations and manuscripts for publication
  • Developing and authoring SOPs, IACUC protocols, study protocols, reports and other scientific and quality documents
Required Qualifications:
  • PhD in neuroscience (or equivalent) with demonstrated productivity in the neuroscience field as evidenced by a strong publication record
  • Well-versed in developing in vivo models for preclinical studies
  • Expertise in rodent neuroanatomy, stereotaxic surgery, animal behavior and histology
  • Excellent analytical, problem solving, and organizational skills with attention to detail
  • Proven ability to work as a member of an interdisciplinary team and contribute in a highly collaborative environment
  • Excellent communication skills with the ability to thoroughly document and effectively present scientific data
  • High energy and passion for drug discovery and development

 
 
 

Head of Quality Assurance

The Director of Quality Assurance will be responsible for implementing and leading all Quality programs and ensuring compliance with all relevant domestic and international regulatory guidelines as they pertain to Neurona’s cell-based product candidates.

Responsibilities include:
  • Drive the development of the company’s Quality strategy and policies.
  • Oversee company-wide documentation practices, record keeping, training, auditing, raw material qualification and risk assessment, SOPs, batch records, study protocols, reports, investigations, analytical methods, and release specifications.
  • Lead all QA efforts and documentation for the compliant manufacturing of lead product candidates. Responsible for release or rejection of GMP cell banks, reagents, and products.
  • Provide Quality Assurance and compliance oversight for contract manufacturers and research organizations to ensure products/deliverables meet all required quality standards and specifications.
  • Collaborate with other department heads of Process Development and Manufacturing, Preclinical Development, and Regulatory Affairs to implement proper documentation, maintain compliance, and accelerate product candidates for clinical testing.
  • Draft, review, and approve relevant sections of regulatory filings.
  • Represent QA department at project and leadership team meetings.
Required Qualifications:
  • 10+ years of experience in Quality Assurance at an operational/management level supporting manufacturing and quality control in a pharmaceutical or biotech environment.
  • Experience contributing to and reviewing regulatory filings.
  • Experience with cell and gene therapies, and full understanding of FDA CBER/OTAT guidance documents and requirements.
  • In-depth knowledge of pharmaceutical GMPs and ISOs (US and EU).
  • Prior experience implementing quality systems and advancing novel therapeutics from preclinical stages through IND to BLA is desired.
  • Effectively managed FDA inspections/audits, and conducted supplier/manufacturer audits.
  • Must have excellent verbal, written, and interpersonal communication and presentation skills.
  • Demonstrated ability to manage staff and projects (direct and indirectly) and variable workloads with demanding timelines.
  • Committed to the values of integrity, accountability, transparency, scientific rigor and drive

 
 
 

Research Associate (Discovery Biology)

Neurona Therapeutics is an early stage biotechnology company based in South San Francisco focused on the development of neuronal cell-based therapies for neurological disease. Our ideal candidate is a self-motivated individual who has a passion for scientific research. This is a fantastic opportunity to join a small team, work on transformative science, and take part in building an exciting, science-driven company.

Responsibilities include:
  • Maintain human pluripotent stem cells and differentiated cells.
  • Perform stem cell differentiation into neuronal lineages using a large variety of formats, from 384 well plates to regular and large scale culture vessels.
  • Develop screening cell based assays using automated liquid handler for stem cell differentiation optimization.
  • Utilize High Content Screening (HCS) technology for high-throughput analysis of cell populations.
  • Characterize differentiated cells using a panel molecular biology methods (immuno cyto-chemistry, Flow cytometry, RT-QPCR).
  • Conduct fluorescence or magnetic -activated cell sorting experiments.
  • Prepare tissue culture reagents (media, small molecules, cytokines); Tissue culture room upkeep and restocking.
  • Maintain detailed records.
Required Qualifications:
  • Bachelor’s degree (+2 years of relevant experience) or Master degree in cell/molecular biology or related field.
  • Clear knowledge of sterile tissue culture technique (at least two years experience).
  • Familiar with pluripotent stem cell culture, in vitro directed differentiation paradigms and molecular/functional characterization of derived cell types.
  • Experience with automated liquid handlers to perform medium / high throughput cell based screenings
  • Willing to work a limited number of hours during weekends.
  • Excellent writing, verbal communication, and interpersonal skills.
  • Able to take initiative to improve work processes, develop innovative scientific methodologies and approaches to enhance research productivity.
Preferred Qualifications:
  • At least one year of experience with human pluripotent (embryonic or induced) stem cell maintenance, differentiation, cell sorting and immuno cyto chemistry.
  • One year of experience with lab automation for cell based screening assays using liquid handling automates (protocol creation, hands on automates)
  • Experience with transcript- and protein-based gene expression analyses, high content screening.
  • Knowledge of human developmental biology.

 
 
 

Research Associate (Preclinical Neuroscience)

Neurona Therapeutics is an early stage biotechnology company based in South San Francisco created to develop stem cell-based therapies for neurological disease. Our ideal Research Associate candidate is a self-motivated individual who has clearly demonstrated a passion for scientific research. This is a fantastic opportunity to join a small team, work on transformative science, and take part in building an exciting, science-driven company.

Responsibilities may include:
  • Following experimental protocols
  • Maintaining detailed and accurate records
  • Analyzing data, interpreting and communicating results
  • Processing tissue for histology: Microtome and cryostat sectioning, staining, immunohistochemistry, imaging and analysis
  • Observation and scoring of behavioral assays
  • Analyzing EEG traces
  • Performing basic laboratory procedures, including handling of reagents and preparation of solutions
  • Conducting independent experiments and contributing to collaborative activities
Required qualifications:
  • Previous relevant lab experience and supporting references
  • Strong interpersonal skills with demonstrated ability to contribute to a team
  • Clear, effective written and verbal communication
  • Bachelor’s or Master’s degree (or equivalent) in biology, neuroscience, or a related field

 
 
 

Research Associate (Process Science)

Neurona Therapeutics is an early stage biotechnology company based in South San Francisco focused on the development of neuronal cell-based therapies for neurological diseases. Our ideal candidate is a self-motivated individual who has a passion for scientific research. This is a fantastic opportunity to join a small team, work on transformative science, and take part in building an exciting, science-driven company.

Responsibilities:
  • Prepare cells for cryopreservation and thaw frozen cryovials using aseptic techniques.
  • Preparation and analysis of thawed cell samples by flow cytometry.
  • Perform immunocytochemistry of thawed cell samples.
  • Prepare tissue culture reagents and maintain cell cultures with aseptic techniques.
  • Maintain detailed records in laboratory notebooks, templates and databases.
Required Qualifications:
  • Bachelor’s degree in cell biology, biology or biochemistry.
  • Experience in aseptic handling of mammalian cell culture maintenance.
  • Availability to work a limited number of hours on occasional weekends.
  • Excellent writing, verbal communication, presentation, and interpersonal skills.
  • Able to take initiative to improve work processes, develop innovative scientific methodologies and approaches to enhance research productivity.
Preferred Qualifications:
  • 2 years of industrial research experience.
  • Previous experience in cryopreservation and thawing of cells.
  • Strong preference will be given to candidates with experience in aseptic handling of stem cell or neuronal cell culture maintenance and differentiation.
  • 1-2 years of experience in molecular biology (RT-qPCR, RNA-seq etc) and whole-cell (immunocytochemistry and flow cytometry etc) analysis techniques.

 
 
 

For immediate consideration, please email your resume to: jobs@neuronatx.com.

Neurona is proud to be an equal opportunity employer and will consider all qualified applicants for employment.

Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.